Munster centre James Downey is set to make his Ireland debut against Canada in Toronto on Saturday.
Downey replaces of Stuart Olding at inside centre in one of a number of changes to the side that edged out USA last weekend. Andrew Trimble will win his 50th cap for Ireland in a back three that includes Fergus McFadden and Felix Jones. Up front Tom Court joins the front row while Dan Tuohy forms a new second row pairing with Devin Toner. Tommy O'Donnell starts for Ireland having won his first cap last weekend with Kevin McLaughlin and captain Peter O'Mahony completing the back row.
Speaking ahead of the game interim Ireland coach Les Kiss said: "We are anticipating a tough game against a very good Canada side that have put together a run of three wins in the Pacific Nations Cup. The experience gained on this tour is invaluable and I have no doubt that the players will respond well in what will be another challenging test."
Ireland: Felix Jones; Fergus McFadden, Darren Cave, James Downey, Andrew Trimble; Ian Madigan, Isaac Boss; Tom Court, Richardt Strauss, Mike Ross, Dan Tuohy, Devin Toner, Kevin McLaughlin, Tommy O'Donnell, Peter O'Mahony
Replacements: Sean Cronin, David Kilcoyne, Declan Fitzpatrick, Mike McCarthy, Chris Henry, Paul Marshall, Paddy Jackson, Robbie Henshaw