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Ireland will wheel out all available big guns for their final World Cup warm-up match against England at Twickenham on Saturday, except Cian Healy and Rob Kearney.

Head coach Schmidt has refused to risk Healy against Stuart Lancaster's men, allowing the potent loosehead more time to hit full speed after prolonged neck problems.

Healy has only returned to full training this week, following neck surgery in May, and was at one point touch and go even to make Ireland's final World Cup 31.

Simon Zebo slots in at full-back in the absence of regular starter Kearney, with his brother Dave taking the left-wing berth.

Jack McGrath starts in his place at loosehead, with centre Keith Earls not pressed into action, while still undergoing concussion protocols after a heavy blow against Wales last weekend.

Ireland's Kiwi boss Schmidt is able to roll out the heavy artillery elsewhere however, with the visitors seeking a statement result ahead of their World Cup opener against Canada in Cardiff on September 19.

The first-choice back-row of Peter O'Mahony, Sean O'Brien and Jamie Heaslip are reunited for the first time since the Six Nations, with standout half-backs Conor Murray and Johnny Sexton also in tandem.

Fresh from his Test debut in the 16-10 defeat to Wales in Dublin, Tadhg Furlong takes a seat on the bench to cover loosehead prop.

Munster's Donnacha Ryan offers bulk from the bench to impact the second row in the closing stages, with Darren Cave covering midfield among the replacements.

Ireland

S Zebo (Munster), T Bowe (Ulster), J Payne (Ulster), R Henshaw (Connacht), D Kearney (Leinster), J Sexton (Leinster), C Murray (Munster), J McGrath (Leinster), R Best (Ulster), M Ross, D Toner (both Leinster), P O'Connell (Toulon, capt), P O'Mahony (Munster), S O'Brien, J Heaslip (both Leinster).

Replacements: R Strauss, T Furlong (both Leinster), N White (Connacht), D Ryan (Munster), C Henry (Ulster), E Reddan, I Madigan (both Leinster), Darren Cave (Ulster).