Patrick Lambie starts at fullback for the Springboks © Getty Images

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South Africa have made 12 changes for Saturday's showdown with the Barbarians at Twickenham, with promising Sharks youngster Patrick Lambie and Lions playmaker Elton Jantjies making their first starts in a Springbok jersey.

Seven front-line players have been ruled out of the game after suffering injuries in last weekend's 21-11 victory over England. Tour skipper Victor Matfield, Jean de Villiers, Jannie du Plessis, Bismarck du Plessis and Zane Kirchner all miss out.

Jantjies starts at fly-half alongside Francois Hougaard, while Lambie switches to fullback in place of Kirchner. Late call-up Andries Strauss will be thrown straight into action at inside-centre while another player brought in as cover, Odwa Ndungane, starts on the wing.

Flanker Juan Smith captains the side from a much-changes back-row, where Willem Alberts starts at openside and Ryan Kankowski at No.8. Sharks lock Alistair Hargreaves appears for the first time on tour and is joined in the second-row by the experienced Bakkies Botha. CJ van der Linde, Adriaan Strauss and Coenie Oosthuizen pack down in the front-row.

"The newcomers have been waiting for their chance and will bring energy and enthusiasm to the line-up at the end of a long season," De Villiers said. "They have trained well and been patient throughout the tour and this is their chance to show what they can do."

"They [Lambie and Jantjies] are exciting talents and this way they both get maximum opportunity in the match. But I've stressed to them and to all of the team that this match is not about personal performance but about performing as a team - if they do that they will all be successful."

South Africa: P Lambie (Sharks); O Ndungane (Sharks), A Jacobs (Sharks), A Strauss (Sharks), L Mvovo (Sharks); E Jantjies (Lions), F Hougaard (Bulls); C Oosthuizen (Cheetahs), A Strauss (Cheetahs), CJ van der Linde (Cheetahs), B Botha (Bulls), A Hargreaves (Sharks), W Alberts (Sharks), J Smith (Cheetahs), R Kankowski (Sharks)

Replacements: B Maku (Lions), T Mtawarira (Sharks), AN Other, F van der Merwe (Bulls), K Daniel (Sharks), C McLeod (Sharks), G Aplon (Stormers)