Murray last Brit standing after Watson falls
Heather Watson was beaten in three sets by ninth seed Angelique Kerber to leave Andy Murray as the last Brit standing after just four days of play at Wimbledon.
Biritsh No.1 Watson levelled the match having lost the first set but faded in the final set to lose 6-2 5-7 6-1.
The defeat ensures men's defending champion Murray will be Britain's sole representative in the third round singles draws at SW19.
"When I walked off the court I was very upset," said Watson. "I started very poorly. A lot of unforced errors, didn't serve very well. The set kind of went just very quickly."
Having secured a first top-20 win against Flavia Pennetta in Eastbourne last week, world No.60 Watson fell short in her bid for a maiden top-10 win and couldn't equal her best effort at a grand slam by progressing to the third round.
"I am very pleased with where I am now - it was a very tough year for me last year," added Watson.
"The way the year's gone so far, if somebody would've told me that from the beginning of the year, after the year I had last year, I would've taken it."
Watson struggled in the early stages, landing just half of her first serves in an error-strewn first set that Kerber took in 29 minutes.
Watson showed flickers of her Eastbourne form in the second set as she twice recovered breaks and survived four break points at 4-4 before converting a third set point in the 12th game.
However she netted to drop serve in the opening game of the decider before Kerber secured the double break at 3-0.
Watson earned one break back but Kerber won the final three games to end the Brit's challenge and secure a meeting with Belgian 24th seed Kirsten Flipkens in the last 32.