May 1, 1988 Autodromo Enzo e Dino Ferrari | Lap distance 5.040 km
| Pos | Points | No | Driver | Car | Engine | Tyres | Laps | Race Time | Delay | Qualifying | Fastest Lap | |||
| 1 | 9 | 12 | Ayrton Senna (BRA) | McLaren MP4-4 | Honda RA168-E | Goodyear | 60 | 1:32'41.264 | 1 | 1'27.148 | 2 | 1'29.815 | (56) | |
| 2 | 6 | 11 | Alain Prost (FRA) | McLaren MP4-4 | Honda RA168-E | Goodyear | 60 | 1:32'43.598 | +2.334 | 2 | 1'27.919 | 1 | 1'29.685 | (53) |
| 3 | 4 | 1 | Nelson Piquet (BRA) | Team Lotus 100T | Honda RA168-E | Goodyear | 59 | 1:32'48.824 | +1 lap | 3 | 1'30.500 | 9 | 1'32.414 | (57) |
| 4 | 3 | 20 | Thierry Boutsen (BEL) | Benetton B188 | Ford Cosworth DFR | Goodyear | 59 | 1:32'49.373 | +1 lap | 8 | 1'31.414 | 7 | 1'32.317 | (55) |
| 5 | 2 | 28 | Gerhard Berger (AUT) | Ferrari F1/87-88C | Ferrari 156/88 | Goodyear | 59 | 1:32'50.096 | +1 lap | 5 | 1'30.683 | 3 | 1'31.394 | (56) |
| 6 | 1 | 19 | Alessandro Nannini (ITA) | Benetton B188 | Ford Cosworth DFR | Goodyear | 59 | 1:32'55.735 | +1 lap | 4 | 1'30.590 | 6 | 1'32.034 | (57) |
| 7 | 18 | Eddie Cheever (USA) | Arrows A10B | Megatron | Goodyear | 59 | 1:33'35.119 | +1 lap | 7 | 1'31.300 | 5 | 1'32.017 | (49) | |
| 8 | 2 | Satoru Nakajima (JPN) | Team Lotus 100T | Honda RA168-E | Goodyear | 59 | 1:34'01.638 | +1 lap | 12 | 1'31.647 | 12 | 1'33.209 | (58) | |
| 9 | 17 | Derek Warwick (GBR) | Arrows A10B | Megatron | Goodyear | 58 | 1:32'43.299 | +2 laps | 14 | 1'32.483 | 18 | 1'34.056 | (41) | |
| 10 | 14 | Philippe Streiff (FRA) | AGS JH23 | Ford Cosworth DFZ | Goodyear | 58 | 1:32'56.274 | +2 laps | 13 | 1'32.013 | 19 | 1'34.226 | (41) | |
| 11 | 24 | Luis Perez-Sala (ESP) | Minardi M188 | Ford Cosworth DFZ | Goodyear | 58 | 1:33'01.547 | +2 laps | 18 | 1'33.239 | 17 | 1'34.014 | (57) | |
| 12 | 29 | Yannick Dalmas (FRA) | Lola LC88 | Ford Cosworth DFZ | Goodyear | 58 | 1:33'05.587 | +2 laps | 19 | 1'33.374 | 14 | 1'33.623 | (56) | |
| 13 | 6 | Riccardo Patrese (ITA) | Williams FW12 | Judd CV | Goodyear | 58 | 1:33'11.980 | +2 laps | 6 | 1'30.952 | 10 | 1'32.758 | (32) | |
| 14 | 3 | Jonathan Palmer (GBR) | Tyrrell 017 | Ford Cosworth DFZ | Goodyear | 58 | 1:33'13.881 | +2 laps | 23 | 1'33.972 | 15 | 1'33.660 | (54) | |
| 15 | 15 | Mauricio Gugelmin (BRA) | March 881 | Judd CV | Goodyear | 58 | 1:33'24.672 | +2 laps | 20 | 1'33.448 | 16 | 1'33.890 | (55) | |
| 16 | 23 | Adrián Campos (ESP) | Minardi M188 | Ford Cosworth DFZ | Goodyear | 57 | 1:32'55.933 | +3 laps | 22 | 1'33.903 | 22 | 1'35.708 | (39) | |
| 17 | 30 | Philippe Alliot (FRA) | Lola LC88 | Ford Cosworth DFZ | Goodyear | 57 | 1:33'42.950 | +3 laps | 15 | 1'32.712 | 11 | 1'32.863 | (56) | |
| 18 | 27 | Michele Alboreto (ITA) | Ferrari F1/87-88C | Ferrari 156/88 | Goodyear | 54 | 1:25'40.974 | +6 laps | 10 | 1'31.520 | 4 | 1'31.864 | (50) | |
| Not classified | ||||||||||||||
| -- | 33 | Stefano Modena (ITA) | Euro Brun ER-188 | Ford Cosworth DFZ | Goodyear | 52 | 1:32'48.066 | 26 | 1'34.782 | 13 | 1'33.214 | (49) | ||
| Retirement | ||||||||||||||
| gearbox | 4 | Julian Bailey (GBR) | Tyrrell 017 | Ford Cosworth DFZ | Goodyear | 48 | 1:19'35.810 | 21 | 1'33.874 | 20 | 1'35.288 | (48) | ||
| engine | 5 | Nigel Mansell (GBR) | Williams FW12 | Judd CV | Goodyear | 42 | 1:06'21.222 | 11 | 1'31.635 | 8 | 1'32.372 | (35) | ||
| fuel system | 31 | Gabriele Tarquini (ITA) | Coloni FC-188 | Ford Cosworth DFZ | Goodyear | 40 | 1:04'54.130 | 17 | 1'33.236 | 21 | 1'35.395 | (31) | ||
| gearbox | 36 | Alex Caffi (ITA) | Dallara BMS-188 | Ford Cosworth DFZ | Goodyear | 18 | 29'41.447 | 24 | 1'34.204 | 24 | 1'36.285 | (17) | ||
| gearbox | 9 | Piercarlo Ghinzani (ITA) | Zakspeed 881 | Zakspeed 881 | Goodyear | 16 | 26'35.424 | 25 | 1'34.567 | 23 | 1'36.122 | (14) | ||
| gearbox | 16 | Ivan Capelli (ITA) | March 881 | Judd CV | Goodyear | 2 | 3'25.782 | 9 | 1'31.519 | 25 | 1'37.842 | (2) | ||
| suspension | 22 | Andrea de Cesaris (ITA) | Rial ARC-01 | Ford Cosworth DFZ | Goodyear | 0 | 16 | 1'33.037 | ||||||
| Disqualified | ||||||||||||||
| -- | 21 | Nicola Larini (ITA) | Osella FA1L | Osella 890T | Goodyear | 0 | ||||||||
| Not qualified | ||||||||||||||
| -- | 32 | Oscar Larrauri (ARG) | Euro Brun ER-188 | Ford Cosworth DFZ | Goodyear | 1'35.077 | ||||||||
| -- | 26 | Stefan Johansson (SWE) | Ligier JS31 | Judd CV | Goodyear | 1'35.654 | ||||||||
| -- | 25 | René Arnoux (FRA) | Ligier JS31 | Judd CV | Goodyear | 1'36.123 | ||||||||
| -- | 10 | Bernd Schneider (GER) | Zakspeed 881 | Zakspeed 881 | Goodyear | 1'36.218 | ||||||||
