June 19, 1988 Detroit Street Circuit | Lap distance 4.023 km
| Pos | Points | No | Driver | Car | Engine | Tyres | Laps | Race Time | Delay | Qualifying | Fastest Lap | |||
| 1 | 9 | 12 | Ayrton Senna (BRA) | McLaren MP4-4 | Honda RA168-E | Goodyear | 63 | 6.000000.035 | 1 | 0.000 | 2 | 4.000000.992 | (8) | |
| 2 | 6 | 11 | Alain Prost (FRA) | McLaren MP4-4 | Honda RA168-E | Goodyear | 63 | 4.000000.748 | +8.000000.713 | 4 | 2.000000.019 | 1 | 4.000000.836 | (4) |
| 3 | 4 | 20 | Thierry Boutsen (BEL) | Benetton B188 | Ford Cosworth DFR | Goodyear | 62 | 6.000000.536 | +1 lap | 5 | 2.000000.690 | 4 | 5.000000.714 | (13) |
| 4 | 3 | 22 | Andrea de Cesaris (ITA) | Rial ARC-01 | Ford Cosworth DFZ | Goodyear | 62 | 9.000000.837 | +1 lap | 12 | 4.000000.216 | 13 | 7.000000.594 | (4) |
| 5 | 2 | 3 | Jonathan Palmer (GBR) | Tyrrell 017 | Ford Cosworth DFZ | Goodyear | 62 | 3.000000.147 | +1 lap | 17 | 5.000000.268 | 9 | 6.000000.905 | (4) |
| 6 | 1 | 23 | Pierluigi Martini (ITA) | Minardi M188 | Ford Cosworth DFZ | Goodyear | 62 | 0.000 | +1 lap | 16 | 5.000000.048 | 18 | 9.000000.236 | (8) |
| 7 | 29 | Yannick Dalmas (FRA) | Lola LC88 | Ford Cosworth DFZ | Goodyear | 61 | 3.000000.057 | +2 laps | 24 | 6.000000.422 | 22 | 9.000000.946 | (12) | |
| 8 | 36 | Alex Caffi (ITA) | Dallara BMS-188 | Ford Cosworth DFZ | Goodyear | 61 | 0.000 | +2 laps | 21 | 5.000000.750 | 16 | 8.000000.951 | (8) | |
| 9 | 4 | Julian Bailey (GBR) | Tyrrell 017 | Ford Cosworth DFZ | Goodyear | 59 | 1.000000.823 | +4 laps | 22 | 6.000000.286 | 19 | 9.000000.330 | (7) | |
| Retirement | ||||||||||||||
| gearbox | 24 | Luis Perez-Sala (ESP) | Minardi M188 | Ford Cosworth DFZ | Goodyear | 54 | 3.000000.383 | 25 | 6.000000.593 | 26 | 1.000000.855 | (45) | ||
| halfshaft | 30 | Philippe Alliot (FRA) | Lola LC88 | Ford Cosworth DFZ | Goodyear | 46 | 3.000000.926 | 14 | 4.000000.590 | 23 | 0.000 | (37) | ||
| spun off | 33 | Stefano Modena (ITA) | Euro Brun ER-188 | Ford Cosworth DFZ | Goodyear | 46 | 0.000 | 19 | 5.000000.304 | 15 | 8.000000.243 | (9) | ||
| collision | 27 | Michele Alboreto (ITA) | Ferrari F1/87-88C | Ferrari 156/88 | Goodyear | 45 | 9.000000.697 | 3 | 1.000000.700 | 5 | 5.000000.878 | (4) | ||
| overheating | 25 | René Arnoux (FRA) | Ligier JS31 | Judd CV | Goodyear | 45 | 6.000000.455 | 20 | 5.000000.437 | 20 | 9.000000.554 | (8) | ||
| engine | 15 | Mauricio Gugelmin (BRA) | March 881 | Judd CV | Goodyear | 34 | 1.000000.396 | 13 | 4.000000.474 | 17 | 9.000000.224 | (18) | ||
| engine | 6 | Riccardo Patrese (ITA) | Williams FW12 | Judd CV | Goodyear | 26 | 5.000000.112 | 10 | 3.000000.810 | 8 | 6.000000.632 | (5) | ||
| spun off | 1 | Nelson Piquet (BRA) | Team Lotus 100T | Honda RA168-E | Goodyear | 26 | 7.000000.816 | 8 | 3.000000.314 | 11 | 7.000000.137 | (4) | ||
| gearbox | 32 | Oscar Larrauri (ARG) | Euro Brun ER-188 | Ford Cosworth DFZ | Goodyear | 26 | 6.000000.018 | 23 | 6.000000.390 | 21 | 9.000000.782 | (17) | ||
| spun off | 17 | Derek Warwick (GBR) | Arrows A10B | Megatron | Goodyear | 24 | 3.000000.122 | 9 | 3.000000.799 | 10 | 7.000000.030 | (5) | ||
| engine | 5 | Nigel Mansell (GBR) | Williams FW12 | Judd CV | Goodyear | 18 | 0.000 | 6 | 2.000000.897 | 6 | 6.000000.044 | (4) | ||
| suspension | 14 | Philippe Streiff (FRA) | AGS JH23 | Ford Cosworth DFZ | Goodyear | 15 | 4.000000.002 | 11 | 4.000000.204 | 12 | 7.000000.326 | (5) | ||
| suspension | 19 | Alessandro Nannini (ITA) | Benetton B188 | Ford Cosworth DFR | Goodyear | 14 | 9.000000.517 | 7 | 3.000000.117 | 7 | 6.000000.125 | (6) | ||
| electrical | 18 | Eddie Cheever (USA) | Arrows A10B | Megatron | Goodyear | 14 | 5.000000.398 | 15 | 4.000000.948 | 14 | 7.000000.739 | (6) | ||
| engine | 21 | Nicola Larini (ITA) | Osella FA1L | Osella 890T | Goodyear | 7 | 1.000000.526 | 26 | 6.000000.623 | 25 | 0.000 | (7) | ||
| puncture | 28 | Gerhard Berger (AUT) | Ferrari F1/87-88C | Ferrari 156/88 | Goodyear | 6 | 6.000000.366 | 2 | 1.000000.464 | 3 | 5.000000.508 | (3) | ||
| overheating | 26 | Stefan Johansson (SWE) | Ligier JS31 | Judd CV | Goodyear | 2 | 1.000000.668 | 18 | 5.000000.275 | 24 | 0.000 | (2) | ||
| Not started | ||||||||||||||
| -- | 16 | Ivan Capelli (ITA) | March 881 | Judd CV | Goodyear | 5.000000.544 | ||||||||
| Not qualified | ||||||||||||||
| -- | 2 | Satoru Nakajima (JPN) | Team Lotus 100T | Honda RA168-E | Goodyear | 7.000000.243 | ||||||||
| -- | 10 | Bernd Schneider (GER) | Zakspeed 881 | Zakspeed 881 | Goodyear | 8.000000.249 | ||||||||
| -- | 9 | Piercarlo Ghinzani (ITA) | Zakspeed 881 | Zakspeed 881 | Goodyear | 8.000000.925 | ||||||||
| Not pre-qualified | ||||||||||||||
| -- | 31 | Gabriele Tarquini (ITA) | Coloni FC-188 | Ford Cosworth DFZ | Goodyear | 7.000000.312 | ||||||||
